Exercise: The Missing Vital Sign Linked to 19 Chronic Diseases

A groundbreaking study from the University of Iowa has demonstrated that treating physical activity as a “vital sign” during medical checkups could help identify patients at higher risk for numerous chronic health conditions. The research, published in the Centers for Disease Control and Prevention’s journal Preventing Chronic Disease, examined over 40,000 patients to understand the relationship between exercise habits and health outcomes.

The study focused on a simple two-question screening tool called the Exercise Vital Sign (EVS), which asks patients how many days per week they exercise and for how many minutes per session. Based on their responses, patients were categorized as active (150+ minutes per week), insufficiently active (1-149 minutes), or inactive (0 minutes).

The findings revealed that physically active patients had significantly better health profiles across multiple measures. Compared to inactive or insufficiently active patients, those who met recommended exercise levels had lower blood pressure, better cholesterol levels, and reduced risk of up to 19 different chronic conditions, including obesity, depression, diabetes, and heart disease.

Dr. Lucas Carr, one of the study’s lead authors, emphasized the importance of these findings: “Despite the well-documented benefits of physical activity for preventing and managing more than 25 chronic diseases, patients are rarely screened for physical inactivity in primary care settings.”

The research suggests that routine exercise screening during medical visits could help healthcare providers identify at-risk patients earlier and provide appropriate interventions. This approach aligns with recent U.S. Preventive Services Task Force recommendations supporting behavioral counseling for physical activity, especially for patients with cardiovascular risk factors.

While the study found that only a tiny fraction of patients are currently being screened for physical activity levels, the researchers advocate for broader implementation of exercise screening across healthcare systems. They argue that treating physical activity as a vital sign—similar to blood pressure or heart rate—could lead to earlier interventions and better health outcomes.

For the general public, this research underscores the importance of regular physical activity for overall health. The CDC recommends at least 150 minutes of moderate-intensity weekly exercise for adults. The study suggests that meeting these guidelines could significantly reduce the risk of numerous chronic health conditions.

As healthcare systems continue to focus on preventive care, measuring physical activity as a vital sign represents a promising approach to identifying and addressing inactivity-related health risks before they develop into more serious conditions.

Reference: Chapman CG, Schroeder MC, Marcussen B, Carr LJ. Identifying Patients at Risk for Cardiometabolic and Chronic Diseases by Using the Exercise Vital Sign to Screen for Physical Inactivity. Prev Chronic Dis. 2025;22:240149.