Protecting your brain against Alzheimer’s disease

Of all the organs we want to keep operating at peak performance as we age, at the top of the list is our brain. What good is a perfect physique if our brain turns to mush? Reduced levels of brain-derived neurotrophic factor (BDNF) and gamma-aminobutyric acid (GABA) have been found to play key neurochemical roles in the pathophysiology of Alzheimer’s disease (AD). Fortunately, levels of BDNF and GABA can be raised by regular exercise and medical ozone therapy. Depression and poor sleep quality can also contribute to the development and progression of AD, and exercise and ozone therapy can target depression and sleep quality as well. In addition, engaging in social activity and passionate interests and hobbies can help maintain peak brain health. To learn more, please study the links below:

Castrén E, Monteggia LM. Brain-Derived Neurotrophic Factor Signaling in Depression and Antidepressant Action. Biol Psychiatry. 2021 Jul 15;90(2):128-136.

Harerimana NV, Liu Y, Gerasimov ES, Duong D, Beach TG, Reiman EM, Schneider JA, Boyle P, Lori A, Bennett DA, Lah JJ, Levey AI, Seyfried NT, Wingo TS, Wingo AP. Genetic Evidence Supporting a Causal Role of Depression in Alzheimer’s Disease. Biol Psychiatry. 2022 Jul 1;92(1):25-33.

Jiao SS, Shen LL, Zhu C, Bu XL, Liu YH, Liu CH, Yao XQ, Zhang LL, Zhou HD, Walker DG, Tan J, Götz J, Zhou XF, Wang YJ. Brain-derived neurotrophic factor protects against tau-related neurodegeneration of Alzheimer’s disease. Transl Psychiatry. 2016 Oct 4;6(10):e907.

Kline CE. The bidirectional relationship between exercise and sleep: Implications for exercise adherence and sleep improvement. Am J Lifestyle Med. 2014 Nov-Dec;8(6):375-379.

Li Y, Feng X, Ren H, Huang H, Wang Y, Yu S. Low-Dose Ozone Therapy Improves Sleep Quality in Patients with Insomnia and Coronary Heart Disease by Elevating Serum BDNF and GABA. Bull Exp Biol Med. 2021 Feb;170(4):493-498.

Sadeghmousavi S, Eskian M, Rahmani F, Rezaei N. The effect of insomnia on development of Alzheimer’s disease. J Neuroinflammation. 2020 Oct 6;17(1):289.

Sigmundsson H, Dybendal BH, Grassini S. Motion, Relation, and Passion in Brain Physiological and Cognitive Aging. Brain Sci. 2022 Aug 24;12(9):1122.

Solas M, Puerta E, Ramirez MJ. Treatment Options in Alzheimer´s Disease: The GABA Story. Curr Pharm Des. 2015;21(34):4960-71.

Wang R, Holsinger RMD. Exercise-induced brain-derived neurotrophic factor expression: Therapeutic implications for Alzheimer’s dementia. Ageing Res Rev. 2018 Dec;48:109-121.