Published December 1, 2022 by

Protecting your brain against Alzheimer’s disease

Of all the organs we want to keep operating at peak performance as we age, at the top of the list is our brain. What good is a perfect physique if our brain turns to mush? Reduced levels of brain-derived neurotrophic factor (BDNF) and gamma-aminobutyric acid (GABA) have been found to play key neurochemical roles in the pathophysiology of Alzheimer’s disease (AD). Fortunately, levels of BDNF and GABA can be raised by regular exercise and medical ozone therapy. Depression and poor sleep quality can also contribute to the development and progression of AD, and exercise and ozone therapy can target depression and sleep quality as well. In addition, engaging in social activity and passionate interests and hobbies can help maintain peak brain health. To learn more, please study the links below:

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Harerimana NV, Liu Y, Gerasimov ES, Duong D, Beach TG, Reiman EM, Schneider JA, Boyle P, Lori A, Bennett DA, Lah JJ, Levey AI, Seyfried NT, Wingo TS, Wingo AP. Genetic Evidence Supporting a Causal Role of Depression in Alzheimer’s Disease. Biol Psychiatry. 2022 Jul 1;92(1):25-33.

Jiao SS, Shen LL, Zhu C, Bu XL, Liu YH, Liu CH, Yao XQ, Zhang LL, Zhou HD, Walker DG, Tan J, Götz J, Zhou XF, Wang YJ. Brain-derived neurotrophic factor protects against tau-related neurodegeneration of Alzheimer’s disease. Transl Psychiatry. 2016 Oct 4;6(10):e907.

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Li Y, Feng X, Ren H, Huang H, Wang Y, Yu S. Low-Dose Ozone Therapy Improves Sleep Quality in Patients with Insomnia and Coronary Heart Disease by Elevating Serum BDNF and GABA. Bull Exp Biol Med. 2021 Feb;170(4):493-498.

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Sigmundsson H, Dybendal BH, Grassini S. Motion, Relation, and Passion in Brain Physiological and Cognitive Aging. Brain Sci. 2022 Aug 24;12(9):1122.

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Dr. Daniel Thomas, DO, MS

Dr. Daniel Thomas, DO, MS

Dr. Thomas is a highly regarded and sought-after physician whose medical expertise has been shaped by extensive education and refined over 40 years of clinical practice. His work centers on unlocking the science of longevity enhancement and helping people with cancer find a clearer path toward resolution. His strength lies in his scientific curiosity, creative and analytical thinking, and practical application of cutting-edge research. Despite the demands of a busy medical practice, Dr. Thomas devotes 20–30 hours a week outside the office to reviewing the latest scientific literature and consulting with leading scientists to identify promising treatments. He shares his evidence-based insights at ThomasHealthBlog.com and in his forthcoming book, “Healthier After 50: A Smarter Path to Aging Well,” which will distill decades of clinical wisdom into a practical guide for living healthier, happier, and longer. Dr. Thomas can be reached at info@healthyandstrong.com.