Researchers at Osaka City University in Japan found that a nasal spray containing a combination of the antibiotic rifampicin and the natural compound resveratrol significantly improved the cognitive function of mice with Alzheimer’s disease, frontotemporal dementia, and Parkinson’s dementia (dementia with Lewy bodies). Dementia is thought to occur when proteins called amyloid-beta, tau, and alpha-synuclein cluster together and form sticky oligomers that accumulate in the brain and impair cognitive function. The combination of intranasal rifampicin and resveratrol inhibited the accumulation of these oligomers and restored synaptophysin levels—a presynaptic protein that facilitates normal synaptic function.
Comments: To take this further, in addition to intranasal rifampicin and resveratrol, I recommend considering oral lithium and fisetin and intravenous ozone to target the numerous mechanisms that lead to “cognitive frailty,” as well as injectable glycyl-L-histidyl-L-lysine to promote favorable gene expression relevant to the health and function of the central nervous system, and intranasal oxytocin to help restore hippocampal synaptic plasticity.
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